Naked mole rats do experience cellular senescence, yet they continue to live long, healthy lives; eliminating the senescence mechanism is not the key to their long life span.
The researchers found that although naked mole rats exhibited cellular senescence similar to mice, their senescent cells also displayed unique features that may contribute to their cancer resistance and longevity. The cellular senescence mechanism permanently arrests a cell to prevent it from dividing, but the cell still continues to metabolize. The researchers found that naked mole rats are able to more strongly inhibit the metabolic process of the senescent cells, resulting in higher resistance to the damaging effects of senescence.
In the naked mole rat, everything is more organized. We believe this is beneficial for longevity and cancer resistance.
Please consider downloading the latest version of Internet Explorer to experience this site as intended. This knowledge — that selection pressure changes with age in a way that depends not just on the expected lifespan but also on the timing of reproductive effort — is fundamental to evolutionary theories of ageing. It is also fundamental to how we design and interpret the research that aims to help us prolong our own maximum lifespans. Many of the species most frequently studied by biologists — such as mice, flies and worms — are chosen precisely because their short lifespans and fast generational turnover make them quicker and easier to work with.
But their short lives and adaptable reproductive strategies actually make them unsuitable models for testing drugs or other anti-ageing interventions aimed at slowing human ageing. This strategy makes sense for species whose brief lives can be subject to wide variability in environmental conditions. For a small rodent, having a litter of pups would be rather pointless if food is too scarce for them to grow and survive to adulthood.
Hamsters, for example, can instead enter a torpid state that actually protects their cells from ageing over winter. Black Mice. How do I stop mice from getting inside the house?
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